A College student named Wim van Eck has created a version of Pac-Man which pits the player against real life crickets unwittingly controlling the ghosts in the game.

The aim of the project was to analyze the "advantages and disadvantages of real-time behaviour of live animals in comparison to behavior-generating code in computer games".

The color detecting system picks up the movements of the crickets in the model maze and then maps them onto the game.

And it seems the crickets put up a bit more of a challange than the computer controlled enemies, At one point a cricket was said to have shed its skin – effectively making it invisable to the color detector for a few seconds (cheat!).

More info can be found at Pixelsix.org